The former Friends star has also told of how her new series The Morning Show had to be altered after the wave of allegations against producer Harvey Weinstein in 2017 prompted many within the entertainment industry to share their own experiences of sexual misconduct.
The Apple TV drama will go behind the scenes at talk shows in New York while exploring the power dynamic between men and women in the workplace.
Aniston, who also executive produces the programme, told Radio Times magazine that they have "had to regroup and redirect the show to include all that stuff" thanks to the shockwaves caused by MeToo.
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She said: "We want it to be raw and honest and vulnerable and messy, and not black and white."
The 50-year-old star also claims she believes there are more allegations to come in the future.
"Incredible things have happened in the past couple of years that were long overdue."
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"It's been a very exciting time and you can see the changes regarding women being objectified, and regarding power and positions of power.
"And I feel a lot more will come to the surface because people are doing their homework and digging deep into everybody's underwear drawer."
Weinstein, who is facing rape charges in New York, has been shunned from Hollywood while a string of other high-profile men have been accused of assault.
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The star who recently broke the internet after she joined Instagram claims that Weinstein also attempted to force her to wear a dress designed by his then-wife.
Having found fame playing Rachel Green in sitcom Friends 25 years ago, Aniston said that she has largely "had a pretty easy time in terms of my experience in the business" regarding gender equality.
She added: "But even back on Friends, it wasn't so much about women being paid the same as men – some of the women were being paid more. It was more about, 'We're doing equal work and we all deserve to be compensated in the same way'.
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"I wouldn't feel good going to work knowing someone was getting X amount and I was getting something greater."
Reece Witherspoon also acts as an executive producer on The Morning Show, said that more and more women are having their voices heard in Hollywood
She said: "Jen and I probably wouldn't have been able to make this show 10 years ago – but now people are taking us more seriously as creators and producers."
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