Isabelle Wheatley, 13, and "vulnerable" Jamie Darlow, 15, sparked panic after disappearing in Essex on Friday.
Isabelle’s mum, Kate Hickmore, urged anyone with information to get in touch with the police.
She told the East Anglian Daily Times: "She is very loved and missed and we want her home safe and sound as quickly as possible."
“If anyone has any knowledge of her whereabouts then please report it to 101.”
Isabelle is 5ft 3in tall and has very long brown hair.
She has hazel eyes and may be wearing a green hooded top, blue jeans and black Adidas trainers.
"Vulnerable" Jamie, who likes to be called Billy, is 5ft 11in tall and has short spiked blonde hair and blue eyes.
If seen, members of the public are asked to approach him with sensitivity.
Jamie was last seen wearing light grey skinny jeans, dark and light grey Nike Air Max trainers and a grey Armani hooded sweatshirt.
People can contact officers at Colchester Local Policing Team on 101 with any information.
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