Officers were called to a house on South Market Road at 10.20pm last night where a man in his 50s had suffered serious injuries.
He was taken to the James Paget Hospital by ambulance but sadly died shortly after his arrival.
Norfolk Constabulary say a man in his 60s and a woman in her 50s, both from the Great Yarmouth area, were arrested in connection with the incident.
They have been taken into police custody for questioning.
Chief Superintendent Chris Balmer said: "Clearly we are still in the early stages of our investigation and our enquiries remain ongoing.
"However, it appears that the suspect and the victim were known to each other and we do not believe there to be any threat to the wider public.”
A cordon has been put in place at the address while officers carry out their enquiries.
Anyone with information should contact Norfolk Constabulary on 101 or contact Crimestoppers anonymously on 0800 555 111 or through their Anonymous Online Form at http://www.crimestoppers-uk.org.
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